MITPhysics / Biology8.591J

Systems Biology

planned·~168 hours total

Professor

Jeff Gore

Textbook

An Introduction to Systems Biology: Design Principles of Biological Circuits
Uri Alon · 2nd · ISBN 9781439837177

Prerequisites

18.03 — Differential Equations

Materials

Course page →

Dynamics in biological systems — gene networks, evolution, ecology, population dynamics. Quantitative approach using dynamical systems and probability.

Syllabus

Week 1
Why systems biology? Dynamic models
Week 2
Gene regulation — feedback motifs
Week 3
Auto-regulation; bistability
Week 4
Oscillations in biological circuits
Week 5
Stochastic gene expression
Week 6
Microbial population dynamics
Week 7
Lotka-Volterra; predator-prey
Week 8
Evolutionary dynamics; quasispecies
Week 9
Game theory in biology
Week 10
Cooperation; tragedy of the commons
Week 11
Ecosystem dynamics; biodiversity
Week 12
Synthetic biology — engineering circuits